Anti-Flavine bevattende mono-zuurstof 4/FMO4 Antibody Picoband® fluoro550 Vervoeging

FMO4 (Flavin-containing monooxygenase 4) also known as FMO2, FORMERLY or FMO, ADULT LIVER FORM, is an enzyme that in humans is encoded by the FMO4 gene. By PCR analysis, Dolphin et al. (1992) mapped the FMO4 gene to chromosome 1. Southern blot hybridization with single exon probes demonstrated that human FMO4 and FMO1 are, in each case, the product of a single gene. Lawton et al. (1994) proposed a reclassification of mammalian FMOs. Under this system, FMO2 described by Dolphin et al. (1992) is now designated FMO4.

Dimethylaniline monooxygenase [N-oxide-forming] 4;1.14.13.8; Dimethylaniline oxidase 4; Hepatic flavin-containing monooxygenase 4; FMO 4; FMO4; FMO2

FMO4

2329

P31512

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human Flavin containing monooxygenase 4, different from the related rat sequence by two amino acids, and from the related mouse sequence by three amino acids.

Liver.

Flow Cytometry

Drug Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.

1. Dolphin, C. T., Shephard, E. A., Povey, S., Smith, R. L., Phillips, I. R. Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family. Biochem. J. 287: 261-267, 1992. 2. Lawton, M. P., Cashman, J. R., Cresteil, T., Dolphin, C. T., Elfarra, A. A., Hines, R. N., Hodgson, E., Kimura, T., Ozols, J., Phillips, I. R., Philpot, R. M., Poulsen, L. L., Rettie, A. E., Shephard, E. A., Williams, D. E., Ziegler, D. M. A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. Arch. Biochem. Biophys. 308: 254-257, 1994. 3. Phillips, I. R., Dolphin, C. T., Clair, P., Hadley, M. R., Hutt, A. J., McCombie, R. R., Smith, R. L., Shephard, E. A.The molecular biology of the flavin-containing monooxygenases of man. Chem. Biol. Interact. 96: 17-32, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

63343 MW

No cross reactivity with other proteins.

6

Dimethylaniline monooxygenase [N-oxide-forming] 4

Microsome membrane. Endoplasmic reticulum membrane.

Belongs to the FMO family.

Dimethylaniline monooxygenase [N-oxide-forming] 4

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.