Anti-GPR161 Antibody Picoband® fluoro488 Vervoeging

G-protein coupled receptor 161 is a protein that in humans is encoded by the GPR161 gene. The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer.

Neutrophil defensin 1; Defensin, alpha 1; HNP-1; HP-1; HP1; HP 1-56; Neutrophil defensin 2; HNP-2; HP-2; HP2; DEFA1; DEF1, DEFA2, MRS; DEFA1B

GPR161

23432

Q8N6U8

Human, Mouse, Rat

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence at the C-terminus of human GPR161, identical to the related mouse sequences.

Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

Flow Cytometry

Defensin, Human Protein, Immunology, Innate Immunity, Macrophage/Inflammation, Microbiology, Protein, Secreted Molecules

Immunogen affinity purified.

Liquid

Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. .

1. Gross, M. B. Personal Communication. Baltimore, Md. 9/30/2015. 2. Karaca, E., Buyukkaya, R., Pehlivan, D., Charng, W.-L., Yaykasli, K. O., Bayram, Y., Gambin, T., Withers, M., Atik, M. M., Arslanoglu, I., Bolu, S., Erdin, S., Buyukkaya, A., Yaykasli, E., Jhangiani, S. N., Muzny, D. M., Gibbs, R. A., Lupski, J. R. Whole-exome sequencing identifies homozygous GPR161 mutation in a family with pituitary stalk interruption syndrome. J. Clin. Endocr. Metab. 100: E140-E147, 2015. Note: Electronic Article. 3. Matteson, P. G., Desai, J., Korstanje, R., Lazar, G., Borsuk, T. E., Rollins, J., Kadambi, S., Joseph, J., Rahman, T., Wink, J., Benayed, R., Paigen, B., Millonig, J. H. The orphan G protein-coupled receptor, Gpr161, encodes the vacuolated lens locus and controls neurulation and lens development. Proc. Nat. Acad. Sci. 105: 2088-2093, 2008.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

10201 MW

6

Neutrophil defensin 1

Secreted.

Neutrophil defensin 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.