Anti-GSK3 beta/GSK3B Antibody Picoband® fluoro550 Vervoeging

Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease.

Fibrinogen gamma chain; FGG; PRO2061

GSK3B

2932

P49841

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human GSK3 beta/GSK3B recombinant protein (Position: M1-T420) .

Detected in blood plasma (at protein level) . .

Flow Cytometry

Neurodegenerative Disease, Neurology Process, Neuroscience

Immunogen affinity purified.

Liquid

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. .

1. Ali, A., Hoeflich, K. P., Woodgett, J. R. Glycogen synthase kinase-3 : properties, functions, and regulation. Chem. Rev. 101: 2527-2540, 2001. 2. Aoukaty, A., Tan, R. Role for glycogen synthase kinase-3 in NK cell cytotoxicity and X-linked lymphoproliferative disease. J. Immun. 174: 4551-4558, 2005. 3. Beaulieu, J.-M., Zhang, X., Rodriguiz, R. M., Sotnikova, T. D., Cools, M. J., Wetsel, W. C., Gainetdinov, R. R., Caron, M. G. Role of GSK3-beta in behavioral abnormalities induced by serotonin deficiency. Proc. Nat. Acad. Sci. 105: 1333-1338, 2008.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

51512 MW

6

Fibrinogen gamma chain

Secreted .

Fibrinogen gamma chain

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.