Anti-GST3/GST pi/GSTP1 Antibody Picoband® 31.0550 Vervoeging

Glutathione S-transferases pi, also known as GST3, present in all tissues and cells, with the exception of red cells, in which only erythrocyte GST (GSTe) is observed. The GST-pi gene has 7 exons and 6 introns contained within approximately 2.8 kilobases. The GST-pi gene is mapped to chromosome 11. Placental glutathione-S-transferase-pi mRNA is abundantly expressed in human skin. GSTP does not contribute in vivo to the formation of glutathione conjugates of acetaminophen but plays a novel and unexpected role in the toxicity of this compound.

Glutathione S-transferase P;2.5.1.18; GST class-pi; GSTP1-1; GSTP1; FAEES3, GST3

GSTP1

2950

P09211

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human GST3/GST pi, different from the related rat and mouse sequences by two amino acids.

Flow Cytometry

Cancer, Cardiovascular, Metabolism, Mitochondrial Markers, Mitochondrial Metabolism, Neurogenesis, Neurology Process, Neuroscience, Oxidative Stress, Pathways and Processes, Redox Metabolism

Immunogen affinity purified.

Liquid

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. .

1. Morrow, C. S.; Cowan, K. H.; Goldsmith, M. E. : Structure of the human genomic glutathione S-transferase-pi gene. Gene 75: 3-11, 1989 2. Islam, M. Q.; Platz, A.; Szpirer, J.; Szpirer, C.; Levan, G.; Mannervik, B. : Chromosomal localization of human glutathione transferase genes of classes alpha, mu and pi. Hum. Genet. 82: 338-342, 1989. Konohana, A.; Konohana, I.; Schroeder, W. T.; O'Brien, W. R.; Amagai, M.; Greer, J.; Shimizu, N.; Gammon, W. R.; Siciliano, M. J.; Duvic, M. :Placental glutathione-S-transferase-pi mRNA is abundantly expressed in human skin. J. Invest. Derm. 95: 119-126, 199

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

23356 MW

No cross reactivity with other proteins.

6

Glutathione S-transferase P

Cytoplasm . Mitochondrion . Nucleus . The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.

Belongs to the GST superfamily. Pi family.

Glutathione S-transferase P

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.