Anti-histone deacetylase 2 HDAC2 Antibody Picoband® fluoro594 Vervoeging

Histone deacetylase 2 is an enzyme that in humans is encoded by the HDAC2 gene. This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4) . This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Betz et al. (1998) performed PCR using HDAC2-specific primers to screen a somatic cell hybrid mapping panel. They mapped the HDAC2 gene to human chromosome 6q21, a region of the genome altered in some cancers, including retinoblastoma.

Histone deacetylase 2; HD2;3.5.1.98; HDAC2

HDAC2

3066

Q92769

Rat, Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human HDAC2, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.

Widely expressed; lower levels in brain and lung.

Flow Cytometry

Acetylation, Cardiovascular, Chromatin Modifying Enzymes, Class I, Epigenetics and Nuclear Signaling, Hypertrophy, Signaling Pathways, Stem Cells

Immunogen affinity purified.

Liquid

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. .

1. Betz R, Gray SG, Ekstrom C, Larsson C, Ekstrom TJ (Dec 1998) . Human histone deacetylase 2, HDAC2 (Human RPD3), is localized to 6q21 by radiation hybrid mapping.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

55364 MW

No cross reactivity with other proteins.

6

Histone deacetylase 2

Nucleus . Cytoplasm .

Belongs to the histone deacetylase family. HD type 1 subfamily.

Histone deacetylase 2 (HD2)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.