Anti-Insulin/IRDN (beta-Cell & Insulinoma Marker) Monoklonale antilichamen (Klone: K36aC10)

Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected throμgh the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.

IDDM2, ILPR, IRDN, MODY10, Proinsulin

INS

3630

P01308

Human

Purified human insulin

K36aC10

FACS, IF, IHC

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Flow Cytometry (1-2ug/million cells) ; Immunofluorescence (1-2ug/ml) ; Immunohistochemistry (Formalin-fixed) (0.1-0.2ug/ml for 30 minutes at RT) (No special pretreatment is required for staining of formalin/paraffin tissues.)

Mouse IgG1, kappa