Anti-KHSRP Antibody Picoband® (monoklonaal, 4F10D2) 310647 Vervoeging

Far upstream element-binding protein 2 is a protein that in humans is encoded by the KHSRP gene. The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization.

N-myc-interactor; Nmi; N-myc and STAT interactor; NMI

KHSRP

8570

Q92945

Human

No cross-reactivity with other proteins.

E.coli-derived human KHSRP recombinant protein (Position: D116-R478) .

Clone: 4F10D2

Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver.

Flow Cytometry

Cytoskeleton, Cytoskeleton/ECM, Motor Proteins, Myosin, Signal Transduction

Immunogen affinity purified.

Liquid

May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.

1. Briata, P., Forcales, S. V., Ponassi, M., Corte, G., Chen, C.-Y., Karin, M., Puri, P. L., Gherzi, R. p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Molec. Cell 20: 891-903, 2005. 2. Davis-Smyth, T., Duncan, R. C., Zheng, T., Michelotti, G., Levens, D. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. J. Biol. Chem. 271: 31679-31687, 1996. 3. Gherzi, R., Lee, K.-Y., Briata, P., Wegmuller, D., Moroni, C., Karin, M., Chen, C.-Y. A KH domain RNA binding protein, KSRP, promotes ARE-ed mRNA turnover by recruiting the degradation machinery. Molec. Cell 14: 571-583, 2004.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

N-myc (and STAT) interactor

Cytoplasm.

Mouse IgG2b

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.