Anti-MAP1B Antibody Picoband® APC-vervoeging

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system.

MAP1B; Microtubule-associated protein 1B; MAP-1B [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]

MAP1B

4131

P46821

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human MAP1B recombinant protein (Position: H102-R1849) . Human MAP1B shares 89.9% and 89.2% amino acid (aa) sequence identity with mouse and rat MAP1B, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Allen, E., Ding, J., Wang, W., Pramanik, S., Chou, J., Yau, V., Yang, Y. Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival. Nature 438: 224-228, 2005. 2. Cui, L., Zheng, J., Zhao, Q., Chen, J.-R., Liu, H., Peng, G., Wu, Y., Chen, C., He, Q., Shi, H., Yin, S., Friedman, R. A., Chen, Y., Guan, M.-X. Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss. JCI Insight 5: e136046, 2020. 3. Edelmann, W., Zervas, M., Costello, P., Roback. L., Fischer, I., Hammarback, J. A., Cowan, N., Davies, P., Wainer, B., Kucherlapati, R. Neuronal abnormalities in microtubule-associated protein 1B mutant mice. Proc. Nat. Acad. Sci. 93: 1270-1275, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

271 kDa

6

Microtubule associated protein 1B

Microtubule-associated protein 1B

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.