Anti-Metalloproteïnaseremmer 4 TIMP4 Antibody Picoband® fluoro594 Vervoeging

Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene. And this gene is mapped to chromosome 3p25. This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.

Metalloproteinase inhibitor 4; Tissue inhibitor of metalloproteinases 4; TIMP-4; TIMP4

TIMP4

7079

Q99727

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP4, different from the related rat sequence by two amino acids, and from the related mouse sequence by three amino acids.

Abundant in heart and present at low levels in many other tissues.

Flow Cytometry

Angiogenesis, Cancer, Cardiovascular, Cell Biology, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Protease Inhibitors, Proteolysis/Ubiquitin

Immunogen affinity purified.

Liquid

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9.

1. Entrez Gene: THPO TIMP4 (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor) . 2. Olson TM, Hirohata S, Ye J, Leco K, Seldin MF, Apte SS (Sep 1998) . Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively. Genomics. 51 (1) : 148–151.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

25503 MW

No cross reactivity with other proteins.

6

Metalloproteinase inhibitor 4

Secreted.

Belongs to the protease inhibitor I35 (TIMP) family.

Metalloproteinase inhibitor 4

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.