Anti-Mitochondriale Pyruvaatdehydrogenase kinase 1/PDK1 Antibody Picoband® fluoro488 Vervoeging

PDK1 (Pyruvate Dehydrogenase Kinase Isoenzyme 1), is an enzyme that in humans is encoded by the PDK1 gene. To find human PDKs, Gudi et al. (1995) used oligonucleotide primers to screen a human liver cDNA library by PCR. They identified and reported the deduced amino acid sequences of PDK1, PDK2, and PDK3. The human PDK1 gene encodes a protein with a predicted molecular mass of 49,244 Da that shares 93% identity with that of the rat PDK1 gene. Northern blot analysis showed that the PDK1 message was expressed predominantly in the heart.

[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 1, mitochondrial;2.7.11.2; Pyruvate dehydrogenase kinase isoform 1; PDH kinase 1; PDK1; PDHK1

PDK1

5163

Q15118

Human, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Mitochondrial Pyruvate dehydrogenase kinase 1, different from the related rat sequence by one amino acid, and from the related mouse sequence by two amino acids.

Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas. .

Flow Cytometry

Cancer, Cancer Metabolism, Carbohydrate Metabolism, Chromatin Modifying Enzymes, Energy Metabolism, Energy Transfer Pathways, Epigenetics and Nuclear Signaling, Integration Of Energy, Integration Of Energy Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Carbohydrates, Methylation, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Oncoproteins/Suppressors, Pathways and Processes, Signal Transduction, Tumor Suppressors

Immunogen affinity purified.

Liquid

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. .

1. Gudi, R., Bowker-Kinley, M. M., Kedishvili, N. Y., Zhao, Y., Popov, K. M. Diversity of the pyruvate dehydrogenase kinase gene family in humans. J. Biol. Chem. 270: 28989-28994, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

49244 MW

No cross reactivity with other proteins.

6

[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 1, mitochondrial

Mitochondrion matrix .

Belongs to the PDK/BCKDK protein kinase family.

[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 1, mitochondrial

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.