Anti-Neurokinine 1 Receptor/TACR1 Antibody Picoband® fluoro488 Vervoeging

The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. Tachykinin receptor 1 consists of 407 amino acid residues, and it has a molecular weight of 58.000. Tachykinin receptor 1, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane (TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for a disulfide bridge, Asp-Arg-Tyr, which is responsible for association with arrestin and, Lys/Arg-Lys/Arg-X-X-Lys/Arg, which interacts with G-proteins.The tachykinin receptor 1 can be found in both the central and peripheral nervous system. It is present in neurons, brainstem, vascular endothelial cells, muscle, gastrointestinal tracts, genitourinary tract, pulmonary tissue, thyroid gland and different types of immune cells. The binding of SP to the tachykinin receptor 1 has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation. Tachykinin receptor 1 antagonists have also been studied in migraine, emesis and psychiatric disorders. In fact, aprepitant has been proved effective in a number of pathophysiological models of anxiety and depression. Other diseases in which the tachykinin receptor 1 system is involved include asthma, rheumatoid arthritis and gastrointestinal disorders.

Substance-P receptor; SPR; NK-1 receptor; NK-1R; Tachykinin receptor 1; TACR1; NK1R, TAC1R

TACR1

6869

P25103

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human TACR1, identical to the related rat and mouse sequences.

Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule. .

Flow Cytometry

Neuropeptides, Neuroscience, Neurotransmitter

Immunogen affinity purified.

Liquid

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

1. Castagliuolo, I., Riegler, M., Pasha, A., Nikulasson, S., Lu, B., Gerard, C., Gerard, N. P., Pothoulakis, C.Neurokinin-1 (NK-1) receptor is required in Clostridium difficile-induced enteritis.J. Clin. Invest. 101: 1547-1550, 1998. 2. George, D. T., Gilman, J., Hersh, J., Thorsell, A., Herion, D., Geyer, C., Peng, X., Kielbasa, W., Rawlings, R., Brandt, J. E., Gehlert, D. R., Tauscher, J. T., Hunt, S. P., Hommer, D., Heilig, M.Neurokinin 1 receptor antagonism as a possible therapy for alcoholism.Science 319: 1536-1539, 2008. 3. Lai, J.-P., Ho, W. Z., Kilpatrick, L. E., Wang, X., Tuluc, F., Korchak, H. M., Douglas, S. D.Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation.Proc. Nat. Acad. Sci. 103: 7771-7776, 2006.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

46251 MW

No cross reactivity with other proteins.

6

Substance-P receptor

Cell membrane; Multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family.

Substance-P receptor (SPR)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.