Anti-Neurosecretoire proteïne VGF VGF Antibody Picoband® fluoro488 Vervoeging

VGF (VGF, Nerve Growth Factor-Inducible), is a protein and neuropeptide that may play a role in regulating energy homeostasis, metabolism. Canu et al. (1997) noted that rat Vgf encodes a predicted 70-kD polypeptide that shares similarities with the secretogranin/chromogranin family and is found in the secretory granules of subsets of neurons and endocrine cells. By fluorescence in situ hybridization, Canu et al. (1997) assigned the VGF gene to 7q22. Canu et al. (1997) demonstrated that the single-copy human VGF gene spans 6 kb of genomic DNA and contains 2 exons. The entire VGF protein is encoded by exon 2, while exon 1 contains only 5-prime untranslated sequence. The structural organization of the human gene is similar to that described for the rat VGF gene (Salton et al., 1991), and both the translated and the untranslated regions show a high degree of sequence homology to the rat gene.

Neurosecretory protein VGF; Neuroendocrine regulatory peptide-1; NERP-1; Neuroendocrine regulatory peptide-2; NERP-2; Antimicrobial peptide VGF[554-577]; VGF

VGF

7425

O15240

Rat, Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human VGF, different from the related rat and mouse sequences by one amino acid.

Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells. .

Flow Cytometry

Endocrine System, Growth Factors/Hormones, Neurology Process, Neuroscience, Signal Transduction

Immunogen affinity purified.

Liquid

May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system. .

1. Canu, N., Possenti, R., Ricco, A. S., Rocchi, M., Levi, A. Cloning, structural organization analysis, and chromosomal assignment of the human gene for the neurosecretory protein VGF. Genomics 45: 443-446, 1997. 2. Hunsberger, J. G., Newton, S. S., Bennett, A. H., Duman, C. H., Russell, D. S., Salton, S. R., Duman, R. S. Antidepressant actions of the exercise-regulated gene VGF. Nature Med. 13: 1476-1482, 2007. 3. Salton, S. R. J., Fischberg, D. J., Dong, K. W. Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells. Molec. Cell. Biol. 11: 2335-2349, 1991.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

67258 MW

No cross reactivity with other proteins.

6

Neurosecretory protein VGF

Secreted . Cytoplasmic vesicle, secretory vesicle . Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.

Belongs to the nuclear hormone receptor family. NR1 subfamily.

Neurosecretory protein VGF

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.