Anti-Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody Picoband® fluoro550 Vervoeging

CHRNA, also termed ACHRA, is mapped on 2q24-q32.This gene encodes the alpha subunit of the muscle acetylcholine receptor, which is the main target of pathogenic autoantibodies in autoimmune myasthenia gravis. The protein-coding sequence of the human alpha subu gene is divided into 9 exons that correspond to different structural and functional domains of the precursor molecule.

Acetylcholine receptor subunit alpha; CHRNA1; ACHRA, CHNRA

CHRNA1

1134

P02708

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human Nicotinic Acetylcholine Receptor alpha 1, identical to the related rat sequence, different from the related mouse sequence by one amino acid.

Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.

Flow Cytometry

Auditory System, Calcium Channels, Calcium Signaling, Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Receptors / Channels, Sensory System, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

1. Giraud, M.; Taubert, R.; Vandiedonck, C.; Ke, X.; Levi-Strauss, M.; Pagani, F.; Baralle, F. E.; Eymard, B.; Tranchant, C.; Gajdos, P.; Vincent, A.; Willcox, N.; Beeson, D.; Kyewski, B.; Garchon, H.-J. : An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature 448: 934-937, 2007. 2. Noda, M.; Furutani, Y.; Takahashi, H.; Toyosato, M.; Tanabe, T.; Shimizu, S.; Kikyotani, S.; Kayano, T.; Hirose, T.; Inayama, S.; Numa, S. : Cloning and sequence analysis of calf cDNA and human genomic DNA encoding alpha-subunit precursor of muscle acetylcholine receptor. Nature 305: 818-823, 1983.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

54546 MW

No cross reactivity with other proteins.

6

Acetylcholine receptor subunit alpha

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Acetylcholine receptor subunit alpha

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.