Anti-Nogo receptor/NgR1/RTN4R Antilichaam Picoband® 31.0647 Vervoeging

Reticulon 4 receptor (RTN4R) also known as Nogo-66 Receptor (NgR) or Nogo receptor 1 is a protein which in humans is encoded by the RTN4R gene. This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.

Solute carrier family 2, facilitated glucose transporter member 9; Glucose transporter type 9; GLUT-9; Urate transporter; SLC2A9; GLUT9

RTN4R

65078

Q9BZR6

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human Nogo receptor/NgR1/RTN4R recombinant protein (Position: P56-R416) .

Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Isoform 2 is only detected in the apical membranes of polarized renal tubular cells and placenta. Isoform 1 and isoform 2 are detected in kidney membrane (at protein level) .

Flow Cytometry

Signal Transduction

Immunogen affinity purified.

Liquid

Urate transporter, which may play a role in the urate reabsorption by proximal tubules. Does not transport glucose, fructose or galactose.

1. Barton, W. A., Liu, B. P., Tzvetkova, D., Jeffrey, P. D., Fournier, A. E., Sah, D., Cate, R., Strittmatter, S. M., Nikolov, D. B. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. EMBO J. 22: 3291-3302, 2003. 2. Domeniconi, M., Cao, Z., Spencer, T., Sivasankaran, R., Wang, K. C., Nikulina, E., Kimura, N., Cai, H., Deng, K., Gao, Y., He, Z., Filbin, M. T. Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron 35: 283-290, 2002. 3. Fournier, A. E., GrandPre, T., Strittmatter, S. M. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 409: 341-346, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Solute carrier family 2 (facilitated glucose transporter), member 9

Basolateral cell membrane. Multi-pass membrane protein. Plasma membrane. Apical cell membrane. Multi-pass membrane protein. Basolateral cell membrane. Multi-pass membrane protein.

Solute carrier family 2, facilitated glucose transporter member 9

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.