Anti-OPA1 Antibody Picoband®

Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. It is mapped to 3q29. This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis. This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Boster Bio Anti-OPA1 Antibody Picoband® catalog # A00508-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Hereditary hemochromatosis protein; HLA-H; HFE; HLAH

OPA1

4976

O60313

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human OPA1 recombinant protein (Position: D296-Q562) .

Expressed in all tissues tested except brain.

WB, ICC, IF, Flow Cytometry, ELISA

Cofactors, Vitamins/Minerals, Hematopoietic Progenitors, Metabolism, Myeloid, Pathways and Processes, Signal Transduction, Stem Cells, Vitamins/Minerals

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. .

1. Patten DA, Wong J, Khacho M, Soubannier V, Mailloux RJ, Pilon-Larose K, MacLaurin JG, Park DS, McBride HM, Trinkle-Mulcahy L, Harper ME, Germain M, Slack RS (Nov 2014) . OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand. The EMBO Journal 33 (22) : 2676–91. 2. Santarelli R, Rossi R, Scimemi P, Cama E, Valentino ML, La Morgia C, Caporali L, Liguori R, Magnavita V, Monteleone A, Biscaro A, Arslan E, Carelli V (Mar 2015) . OPA1-related auditory neuropathy: site of lesion and outcome of cochlear implantation. Brain 138 (Pt 3) : 563–76.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A00508-1

40108 MW

80-100 kDa

6

Hereditary hemochromatosis protein

Cell membrane ; Single-pass type I membrane protein .

Hereditary hemochromatosis protein

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.