Anti-Pin1 Antibody Picoband® (monoklonaal, 5E5) 31.0647 Vervoeging

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, also called DOD, is an enzyme that in humans is encoded by the PIN1 gene. It is mapped to 19p13.2. The enzyme binds to a subset of proteins and thus plays a role as a post phospho PIN1rol in regulating protein function. Studies have shown that the deregulation of PIN1 may play a pivotal role in various diseases. Notably, the up-regulation of PIN1 may be implicated in certain cancers, and the down-regulation of Pin1 may be implicated in Alzheimer's disease. Inhibitors of PIN1 may have therapeutic implications for cancer and immune disorders. PIN1 activity regulates the outcome of proline-ed kinase (e.g. MAPK, CDK or GSK3) signalling and consequently regulates cell proliferation (in part through control of cyclin D1 levels and stability) and cell survival. PIN1 also has an essential role in maintaining cell proliferation and regulating cyclin D1 function.

Catechol O-methyltransferase; COMT

PIN1

5300

Q13526

Human, Monkey, Rat

No cross-reactivity with other proteins.

E.coli-derived human Pin1 recombinant protein (Position: M1-E163) . Human Pin1 shares 95% amino acid (aa) sequence identity with mouse Pin1.

Clone: 5E5

Brain, liver, placenta, lymphocytes and erythrocytes.

Flow Cytometry

Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Immunology, Integrins, Myeloid, Signal Transduction, Stem Cells

Immunogen affinity purified.

Liquid

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

1. Liou, Y.-C., Ryo, A., Huang, H.-K., Lu, P.-J., Bronson, R., Fujimori, F., Uchida, T., Hunter, T., Lu, K. P. Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc. Nat. Acad. Sci. 99: 1335-1340, 2002. 2. Lu, KP; Finn G; Lee TH; Nicholson LK (Oct 2007) . Prolyl cis-trans isomerization as a molecular timer.Nat. Chem. Biol. (United States) 3 (10) : 619–29.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Catechol-O-methyltransferase

Cytoplasm. Cell membrane. Single-pass type II membrane protein. Extracellular side.

Integrin beta-2

IgG2b

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.