Anti-RAD51L1/RAD51B Antilichaam Picoband® fluoro594 Vervoeging

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata.

RAD51B; RAD51L1; REC2; DNA repair protein RAD51 homolog 2; R51H2; RAD51 homolog B; Rad51B; RAD51-like protein 1

RAD51B

5890

O15315

Human

No cross-reactivity with other proteins

E.coli-derived human RAD51L1/RAD51B recombinant protein (Position: H22-F384) . Human RAD51L1/RAD51B shares 85.8% amino acid (aa) sequence identity with mouse RAD51L1/RAD51B.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Adelman, C. A., Lolo, R. L., Birkbak, N. J., Murina, O., Matsuzaki, K., Horejsi, Z., Parmar, K., Borel, V., Skehel, J. M., Stamp, G., D'Andrea, A., Sartori, A. A., Swanton, C., Boulton, S. J. HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis. Nature 502: 381-384, 2013. 2. Albala, J. S., Thelen, M. P., Prange, C., Fan, W., Christensen, M., Thompson, L. H., Lennon, G. G. Identification of a novel human RAD51 homolog, RAD51B. Genomics 46: 476-479, 1997. Note: Erratum: Genomics 51: 480 only, 1998. 3. Cartwright, R., Dunn, A. M., Simpson, P. J., Tambini, C. E., Thacker, J. Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family. Nucleic Acids Res. 26: 1653-1659, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

42 kDa

6

RAD51 paralog B

DNA repair protein RAD51 homolog 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.