Anti-S100A4 / Metastasine / Calvasculine (Marker van Tumor Metastase) Monoklonale Antilichaam (Clone: CPTC-S100A4-3)

S100A4 belongs to the S100 super-family of proteins containing 2 EF-hand calcium-binding domains. S100A4 has been implicated in the progression and prognosis of several forms of human cancer, e.g. breast, colorectal, gastric, pancreatic and bladder cancer, SCLC and oesophageal squamous cell carcinoma, among others. Poor prognosis associated with high S100A4 expression is accompanied by clear signs of disease progression, e.g. high histological and clinical grades and involvement of lymph nodes.Also indicative of poor prognosis is high S100A4 expression coupled with reduced E-cadherin expression in pancreatic, oral squamous cell carcinoma and in melanoma. S100A4 expression is inversely related with expression of metastasis suppressor nm23 and with prognosis of breast cancer. S100A4 is overexpressed in highly metastatic cancers, which makes it useful as a marker of tumor progression.

S100 calcium-binding protein A4; Calvasculin; CAPL; Fibroblast specific protein 1 (FSP1) ; Leukemia multidrμg resistance associated protein; Malignant transformation suppression 1 (MTS1) ; Metastasin; Placental calcium-binding protein

S100A4

6275

P26447

Human

Recombinant human S100A4 full length protein

CPTC-S100A4-3

FACS, WB, IF

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Flow Cytometry (1-2ug/million cells) ; Immunofluorescence (1-2ug/ml) ; Western Blot (1-2ug/ml)

Mouse IgG2c, kappa