Anti-SHCBP1L Antibody Picoband® fluoro550 Vervoeging

This gene encodes a Src homology 2 domain-binding protein 1-like protein. The encoded protein interacts with heat shock 70 kDa protein 2 and may be involved in maintaining spindle integrity during meiosis. This gene is located in region of chromoso0me 1 encompassing a prostate cancer susceptibility locus.

Transmembrane protein 240; TMEM240; C1orf70

SHCBP1L

81626

Q9BZQ2

Human, Rat

No cross-reactivity with other proteins.

E.coli-derived human SHCBP1L recombinant protein (Position: K171-E506) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Liu, M., Shi, X., Bi, Y., Qi, L., Guo, X., Wang, L., Zhou, Z., Sha, J. SHCBP1L, a conserved protein in mammals, is predominantly expressed in male germ cells and maintains spindle stability during meiosis in testis. Molec. Hum. Reprod. 20: 463-475, 2014. 2. Sood, R., Bonner, T. I., Makalowska, I., Stephan, D. A., Robbins, C. M., Connors, T. D., Morgenbesser, S. D., Su, K., Faruque, M. U., Pinkett, H., Graham, C., Baxevanis, A. D., Klinger, K. W., Landes, G. M., Trent, J. M., Carpten, J. D. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. Genomics 73: 211-222, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

19908 MW

6

Transmembrane protein 240

Cell junction, synapse . Cell membrane ; Multi-pass membrane protein .

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.