Anti-Sodium/bile zuur cotransporter SLC10A1 Antibody Picoband® fluoro488 Vervoeging

Na+-taurocholate cotransporting polypeptide (NTCP), also known as SLC10A1 (Solute carrier family 10, member 1), is the major bile acid uptake system in human hepatocytes. NTCP and the ileal transporter ASBT (apical sodium-dependent bile acid transporter) are two sodium-dependent transporters critical for the enterohepatic circulation of bile acids. The hASBT gene is known to be activated by the glucocorticoid receptor (GR) . Ho RH et al. indicates functionally important polymorphisms in NTCP exist and that the like lihood of being carriers of such polymorphisms is dependent on ethnicity.

Sodium/bile acid cotransporter; Cell growth-inhibiting gene 29 protein; Na (+) /bile acid cotransporter; Na (+) /taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1; SLC10A1; NTCP; GIG29

SLC10A1

6554

Q14973

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human SLC10A1, different from the related rat and mouse sequences by one amino acid.

Detected in neutrophils (at protein level) . .

Flow Cytometry

Cancer, Cancer Metabolism, Channels, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Pathways and Processes, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Liquid

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

1. Eloranta JJ, Jung D, Kullak-Ublick GA (2006) . The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism.. Mol. Endocrinol. 20 (1) : 65–79. 2. Ho RH, Leake BF, Roberts RL, et al. (2004) . Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition.. J. Biol. Chem. 279 (8) : 7213–22.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

38119 MW

No cross reactivity with other proteins.

6

Sodium/bile acid cotransporter

Membrane; Multi-pass membrane protein.

Contains 1 RHD (Rel-like) domain.

Sodium/bile acid cotransporter

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.