Anti-TIP49A/RUVBL1 Antibody Picoband® fluoro550 Vervoeging

RuvB-like 1 (E. coli), also known as RUVBL1 and TIP49, is a human gene. This gene encodes a protein that has both DNA-dependent ATPase and DNA helicase activities and belongs to the ATPases associated with diverse cellular activities (AAA+) protein family. The encoded protein associates with several multisubunit transcriptional complexes and with protein complexes involved in both ATP-dependent remodeling and histone modification. Alternate splicing results in multiple transcript variants.

G2/mitotic-specific cyclin-B2; CCNB2

RUVBL1

8607

Q9Y265

Human, Monkey, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human TIP49A/RUVBL1 recombinant protein (Position: Q13-D23) .

Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.

Flow Cytometry

Signal Transduction

Immunogen affinity purified.

Liquid

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

1. Bauer, A., Huber, O., Kemler, R. Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein. Proc. Nat. Acad. Sci. 95: 14787-14792, 1998. 2. Doyon, Y., Selleck, W., Lane, W. S., Tan, S., Cote, J. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Molec. Cell. Biol. 24: 1884-1896, 2004. 3. Fazzio, T. G., Huff, J. T., Panning, B. An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. Cell 134: 162-174, 2008.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

37492 MW

6

Cyclin B2

Centrosome. Microtubule cytoskeleton. Cytosol. Nucleus. Cyclin-dependent protein kinase holoenzyme complex. Cytoplasm. Membrane.

G2/mitotic-specific cyclin-B2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.