Anti-VEGFR2 / CD309 / Flk-1 / KDR3 (Hemangioblast Marker) Monoklonale Antilichaam (Kloon: KDR721)

CD309, also known as VEGFR2, KDR3, and Flk-1 (Mouse), is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Human VEGFR2 is mainly expressed by endothelial cells, embryonic tissues, and megakaryocytes. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGFR2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGFR2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration.

CD309; Fetal liver kinase 1 (FLK-1) ; KDR; Kinase insert domain receptor (a type III receptor tyrosine kinase) ; KRD1; Ly73; Protein tyrosine kinase receptor FLK1; Protein-tyrosine kinase receptor flk-1; Vascular endothelial growth factor receptor 2

KDR

3791

P35968

Human

Recombinant human VEGF-R2 protein

KDR721

FACS, IF, Functional Assay

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Flow Cytometry (1-2ug/million cells) ; Immunofluorescence (1-2ug/ml) ; Functional Studies (Order Ab without BSA & Azide)

Mouse IgG1, kappa