Anti-XIAP Antibody Picoband® (monoklonale, 3G2G1) fluoro488 Vervoeging

XIAP, also known as IAP3 or BIRC4, is a protein that stops apoptotic cell death. It is mapped to chromosome Xq25. This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants.

T-cell surface glycoprotein CD5; Lymphocyte antigen T1/Leu-1; CD5; CD5; LEU1

XIAP

331

P98170

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human XIAP recombinant protein (Position: A15-V244) . Human XIAP shares 89.4% and 90.7% amino acid (aa) sequence identity with mouse and rat XIAP, respectively.

Clone: 3G2G1

Brain, liver, placenta, lymphocytes and erythrocytes.

Flow Cytometry

Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Immunology, Integrins, Myeloid, Signal Transduction, Stem Cells

Immunogen affinity purified.

Liquid

May act as a receptor in regulating T-cell proliferation.

1. Cummins, J. M., Kohli, M., Rago, C., Kinzler, K. W., Vogelstein, B., Bunz, F.X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) -mediated apoptosis in human cancer cells.Cancer Res. 64: 3006-3008, 2004. 2. Deveraux, Q. L., Takahashi, R., Salvesen, G. S., Reed, J. C.X-linked IAP is a inhibitor of cell-death proteases.Nature 388: 300-304, 1997. 3. Kim, J., Park, J., Choi, S., Chi, S.-G., Mowbray, A. L., Jo, H., Park, H.X-linked inhibitor of apoptosis protein is an important regulator of vascular endothelial growth factor-dependent bovine aortic endothelial cell survival.Circ. Res. 102: 896-904, 2008.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

CD5 molecule

Cell membrane; Single-pass type I membrane protein

Integrin beta-2

Mouse IgG1

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.