Antiproteïne Tyrosine Fosfatase, niet-receptortype 6 Monoklonale Antilichaam (Kloon: CPTC-PTPN6-2)

PTPN6, which is also designated as SHP-1, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies sμggest that it may be helpful in differentiating mantle/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative) .

PTPN6; SHP1; protein tyrosine phosphatase, non-receptor type 6; HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; 70 kda SHP-1L protein; hematopoietic cell phosphatase; hematopoietic cell protein-tyrosine phosphatase; protein-tyrosine phosphatase 1C; PTPN6 / SHP

PTPN6

5777

P29350

Human

Recombinant human full-length PTPN6 protein

CPTC-PTPN6-2

ELISA, WB

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

ELISA (For coating, purchase antibody without BSA) ; Western Blot (1-2ug/ml)

Mouse IgG2a, kappa