Antisynucleïne, pan-antilichaam

A family of homologous proteins known as alpha-, beta-, and gamma-synuclein are abundantly expressed in brain, especially in the presynaptic terminal of neurons. Although the precise function of these proteins remains unknown, alpha-synuclein has been implicated in synaptic plasticity associated with avian song learning as well as in the pathogenesis of Parkinson's disease (PD), dementia with LBs (DLB), some forms of Alzheimer's disease (AD), and multiple system atrophy (MSA) .

Our Anti-Pan-synuclein rabbit polyclonal primary antibody detects human, mouse, and rat Pan-synuclein , and is affinity-purified. It is validated for use in FC, WB.

Our Anti-Pan-synuclein rabbit polyclonal primary antibody detects human, mouse, and rat Pan-synuclein, and is affinity-purified. It is validated for use in FC, WB.

P37840; Q16143; O76070

Human, Mouse, and Rat

A synthetic peptide (AKEGVVAAAEKTKQGV) as a consensus part of human alpha-, beta-, and gamma synuclein proteins has been used as the immunogen.

Pan-synuclein

Unconjugated

FC, WB

Affinity-purified

Lyophilized from PBS buffer pH 7.2-7.6 with 0.1% trehalose, and sodium azide

For research use only.

25°C (ambient)

Spin vial briefly before opening. Reconstitute in 100 μL of sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for long-term stability. Working aliquots can be kept at 2-8°C for up to 4 weeks, or longer with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles.

Purified by affinity chromatography against the peptide immunogen.

0.5-2 μg/mL

Validated by Western blotting and flow cytometry. This antibody recognizes human, mouse, rat alpha-, beta- and gamma-synuclein.

Rabbit

Lyophilized

IgG

Human