ANXA7 Antilichaam - N-terminalgebied: HRP (ARP36584_T100-HRP)

Annexin A7

SNX, ANX7, SYNEXIN

310

Q5T0M6

NP_001147

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human ANXA7

ANXA7 is a member of the annexin family of calcium-dependent phospholipid binding proteins. The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly (A) signals. The selection of poly (A) signals is independent of the mRNA splicing pattern. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion.

UBC; PAX8; ATP4A; SRC; Prkcb; Prkcg; Prkca; PRKG1; PRKACA; VCP; ANXA4; CUL4B; CUL5; ALG2; ELAVL1; CCDC90B; WDR18; LRIF1; OTUB1; CPSF3L; SEMA5B; INPP5K; ACTL6B; CSAD; SDF4; MED31; TAF5L; TRMT2A; TUBB2B; CPNE2; ZNF431; KLHL23; DOCK7; WDR73; FBN3; RBM48; ADA

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

0.5 mg/ml

Cow: 86%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

51kDa

Satoh, H., et al., (2002) Biochim. Biophys. Acta 1600 (1-2), 61-67

Wet Ice

466

ANXA7

ANXA7

Rabbit

Annexin A7

NM_001156

MSYPGYPPTGYPPFPGYPPAGQESSFPPSGQYPYPSGFPPMGGGAYPQVP