APEX1 Antilichaam - N-terminalgebied: HRP (ARP32651_T100-HRP)

APEX nuclease (multifunctional DNA repair enzyme) 1

APE, APX, APE1, APEN, APEX, HAP1, REF1

328

P27695

NP_542379

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human APEX1

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells.

GADD45A; UBC; RPA3; RPA2; RPA1; rev; CCDC124; RIC8A; PABPC1; TWF2; XPOT; HNRNPUL1; ARIH2; PAPSS2; NAE1; PSMG1; TXNRD1; TXN; TCEB1; LGALS1; HNRNPK; CAPNS1; SRPK2; SRPK1; MUTYH; HMGA1; HMGA2; GZMK; GZMA; YBX1; EP300; ASCL2; STAT3; SNRPD1; SFPQ; APP; UBE2I

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

APEX1 is supported by BioGPS gene expression data to be expressed in HepG2

0.5 mg/ml

Cow: 92%; Dog: 92%; Goat: 83%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 92%; Rat: 92%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

35kDa

Ding, S.Z., et al., (2004) Gastroenterology 127 (3), 845-858

Wet Ice

318

APEX1

APEX1

Rabbit

DNA- (apurinic or apyrimidinic site) lyase

NM_080648

KGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGY