Biotinyleerd Cynomolgus IL-23 alfa&IL-12 beta Heterodimer Protein, His, AvitagTM&Tag Free (MALS geverifieerd)

Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Biotinylated Cynomolgus IL-23 alpha&IL-12 beta Heterodimer Protein, His, Avitag&Tag Free, produced by co-expression of IL23A and IL12B, has a calculated MW of 22 kDa (IL23A) & 34.8 kDa (IL12B) . Subunit IL23A is fused with an Avi tag (Avitag™), followed by a polyhistidine tag at the N-terminus and subunit IL12B contains no tag. The protein migrates as 25-27 kDa, 35-38 kDa and 40-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Val 22 - Pro 189 & Ile 23 - Ser 328

IL23A & IL12B

Biotin-labeled

N-10xHis & N-Avi | Native

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

90%

Powder

PBS, pH7.4

22.0 kDa & 34.8 kDa

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RT

-20°C

200ug*1

HEK293

Cynomolgus

G7PIH8 & G7P6S2

Trehalose