CAD Antilichaam - N-terminaal gebied: Biotine (ARP46105_P050-Biotine)

Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

CDG1Z, DEE50, GATD4, EIEE50

790

P27708

NP_004332

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human CAD

CAD is a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

UBC; TUBG1; TP53; SUMO2; SPRTN; STAU1; LGR4; SUMO1; NEDD8; WWOX; NEDD4; FBXO6; HDAC6; ILK; CDK2; HDAC11; HTRA2; TP63; NOS2; ITGA4; RUVBL1; XPO1; VARS; TUBB2A; TUBA4A; SMARCC2; SMARCA4; RPS3; PSMD1; PSMC2; RUVBL2; TUBB4B; SHC1; SMAD2; GRB2; CBL; CUL3; FBXO

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Sheep: 86%; Zebrafish: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

243kDa

Olsen, J.V., (2006) Cell 127 (3), 635-648

Wet Ice

2225

CAD

CAD

Rabbit

CAD protein

NM_004341

AALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILV