CARD8 Antilichaam - N-terminalgebied: HRP (ARP55119_P050-HRP)

Caspase recruitment domain family, member 8

NDPP, DACAR, DAKAR, NDPP1, TUCAN, CARDINAL

22900

Q9Y2G2-2

Human

The immunogen is a synthetic peptide directed towards the N-terminal region of Human CARD8

The protein encoded by this gene belongs to the caspase recruitment domain (CARD) -containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB) . This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.

ELAVL1; CARD16; CARD8; CARD18; NLRP2; NLRP3; FHL2; CASP9; IKBKG; CASP1; CARD6

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Human: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

31kDa

Wet Ice

286

CARD8

CARD8

Rabbit

Caspase recruitment domain-containing protein 8

LGGTFPGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPEGNVDVELID