CD11b (ITGAM) Mouse Monoclonal Antibody [Kloon ID: LBI12C10]

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3') . The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Carrier-free (BSA/glycerol-free) ITGAM mouse monoclonal antibody, clone LBI12C10

CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6

Homo sapiens integrin subunit alpha M (ITGAM), transcript variant 2, mRNA.

3684

P11215

Unconjugated

Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Leukocyte transendothelial migration, Regulation of actin cytoskeleton

Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Leukocyte transendothelial migration, Regulation of actin cytoskeleton

WB 1:500, IHC 1:150

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

ITGAM

https://www.ncbi.nlm.nih.gov/gene/?term=3684

https://www.uniprot.org/uniprot/P11215