Chk2 (Ab 516) Antilichaam

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation

11200

O96017

NP_001005735.1

Human

Chk2 (Ab-516) antibody was raised against a peptide sequence around aa. 514~518 (Q-P-S-T-S) derived from Chk2.

Unconjugated

Primary Antibodies

Cell Cycle

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

62 kDa

This antibody detects endogenous levels of total Chk2 protein.

Western Blot: 1:500~1:1000

CHEK2

Checkpoint kinase 2

This antibody was raised against a peptide sequence around aa. 514~518 (Q-P-S-T-S) derived from Chk2

Melchionna, R. et al. (2000) Nat. Cell Biol. 2, 762-765. Ahn, J. Y. et al. (2000) Cancer Res. 60, 5934-5936. Lee, C. H. and Chung, J. H. (2001) J. Biol. Chem. 276, 30537-30541

CDS1, CHK2, LFS2, RAD53, hCds1, HuCds1, PP1425, NFKB3, CHEK2

WB

54112407

Liquid