CTSC Antilichaam - N-terminalgebied: HRP (ARP60117 P050-HRP)

Cathepsin C

JP, HMS, JPD, PLS, CPPI, DPP1, DPPI, PALS, DPP-I, PDON1

1075

P53634

Human, Rat, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N-terminal region of Human CTSC

CTSC is a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in CTSC have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.

SUMO1; UBC; NEDD8; ARMC9; ANKMY2; ARIH1; UBA2; ADSL; FBXO6; XRN2; CAPN1; CD81; CTSC; CTSL

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB, IHC

Affinity Purified

0.5 mg/ml

Human: 100%; Pig: 79%; Rabbit: 90%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

50kDa

Wet Ice

463

CTSC

CTSC

Rabbit

Dipeptidyl peptidase 1

VNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGD