DAZ1 Antilichaam - N-terminalgebied: HRP (ARP58711 P050-HRP)

Deleted in azoospermia 1

DAZ, SPGY

1617

Q9NQZ3

NP_004072

Human, Mouse, Rat, Cow, Dog, Goat, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human DAZ1

DAZ1 is a RNA-binding protein that plays an essential role in spermatogenesis. DAZ1 may act by binding to the 3'-UTR of mRNAs and regulating their translation.This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF) . Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts containing three copies of the RRM domain have been described; thus the RefSeq for this gene contains only two RRM domains. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

DZIP1L; BOLL; PUM2; DZIP1; QKI; DAZL; UBC; DAZ1; DZIP3; DAZAP2; DAZAP1; DYNLL1

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Goat: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 85%; Rat: 79%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

64kDa

Stouffs, K., (2008) Hum. Reprod. 23 (5), 1193-1199

Wet Ice

579

DAZ1

DAZ1

Rabbit

Deleted in azoospermia protein 1

NM_004081

MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDAR