DEAF1 Antilichaam - N-terminaal gebied: Biotine (ARP39467 P050-Biotine)

Deformed epidermal autoregulatory factor 1 (Drosophila)

SPN, NUDR, VSVS, MRD24, ZMYND5, NEDHELS

10522

O75398

NP_066288

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Yeast

The immunogen is a synthetic peptide directed towards the N terminal region of human DEAF1

DEAF1 down-regulates transcription of those genes by binding to sequence with multiple copies of TTC[CG]G present in their own promoter and that of the HNRPA2B1 gene. DEAF1 binds to the retinoic acid response element (RARE) AGGGTTCACCGAAAGTTCA. DEAF1 activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.

IRF7; IRF3; CREB1; PELI1; PELI2; HRSP12; GSK3B; GSK3A; CDKN2A; PPP1CC; PPP1CA; CDC37; AIMP2; TK1; RAD23B; PIN1; HRAS; FHL1; CDKN1A; ASCC2; INTS1; LMO4; DEAF1

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 83%; Dog: 93%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Yeast: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

59kDa

Czesak, M., (2006) J. Neurosci. 26 (6), 1864-1871

Wet Ice

565

DEAF1

DEAF1

Rabbit

Deformed epidermal autoregulatory factor 1 homolog

NM_021008

EEPVLSRDEDSEEDADSEAERETPRVTAVAVMAAEPGHMDMGAEALPGPD