DTL Antilichaam - N-terminalgebied: HRP (ARP46248_P050-HRP)

Denticleless E3 ubiquitin protein ligase homolog (Drosophila)

CDT2, RAMP, DCAF2, L2DTL

51514

Q9NZJ0

NP_057532

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human DTL

DTL is required for CDT1 proteolysis in response to DNA damage through the CUL4-DDB1 E3 ubiquitin-protein ligase. It seems to be necessary to ensure proper cell cycle regulation of DNA replication. DTL may function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. It also may play a role in cell proliferation of NT2 embryonal carcinoma cells.

FBXO11; YWHAQ; CUL4A; YWHAZ; YWHAH; YWHAG; YWHAE; YWHAB; UBE2D1; UBC; PCNA; SFN; DDB1; FBXO18; CDT1; CUL4B; TDG; LYN; SHPRH; RAD18; COPS5; HLTF; CHEK1; CFTR; CDKN1A; DDA1; COPS4; COPS6; TOB1; COPS3; TUBG1; ATR; AURKB; TP53; MDM2; MSH2; MSH6; KAT2A; Dtl; S

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

DTL is supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

79kDa

Sansam, C.L., (2006) Genes Dev. 20 (22), 3117-3129

Wet Ice

730

DTL

DTL

Rabbit

Denticleless protein homolog

NM_016448

VNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLV