EDEM1 Antilichaam - N-terminalgebied: HRP (ARP47054_P050-HRP)

ER degradation enhancer, mannosidase alpha-like 1

EDEM

9695

Q92611

NP_055489

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Yeast

The immunogen is a synthetic peptide directed towards the N terminal region of human EDEM1

EDEM1 belongs to the glycosyl hydrolase 47 family. It extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner.

HLA-B; SQSTM1; UBC; MMS19; SSR1; ASGR1; DERL1; DNAJC10; DERL2; SEC61B; SEL1L; RHO; CANX; RCOM_2159910; ASGR2; ELAVL1; BZW1

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

EDEM1 is supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Cow: 100%; Dog: 93%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 82%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

74kDa

Zuber, C., (2007) Proc. Natl. Acad. Sci. U.S.A. 104 (11), 4407-4412

Wet Ice

657

EDEM1

EDEM1

Rabbit

ER degradation-enhancing alpha-mannosidase-like 1

NM_014674

MAHAFPQDELNPIHCRGRGPDRGDPSNLNINDVLGNYSLTLVDALDTLAI