Eotaxine-2

Eotaxin-2 is a CC chemokine that signals through the CCR3 receptor. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemoattracts cells expressing CCR3 including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells. The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 a.a. residues for the murine homolog, without C-terminal truncation) . Recombinant murine Eotaxin-2 is an 10.3 kDa protein containing 93 amino acid residues.

Ccl24; CKb-6; MPIF-2; Scya24

56221

Q9JKC0

NP_062523.1

NM_019577

5; 5 G1

Mouse

Mouse, Human

VTIPSSCCTS FISKKIPENR VVSYQLANGS ICPKAGVIFI TKKGHKICTD PKLLWVQRHI QKLDAKKNQP SKGAKAVRTK FAVQRRRGNS TEV

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

Determined by its ability to chemoattract murine lymphocytes using a concentration range of 10-100 ng/ml

93

Lyophilized

10.3 kDa

E. coli