Ethyleendiaminetetraazijnzuur-d16

Ethylenediaminetetraacetic acid-d16 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].

203805-96-3

EDTA-d16

12352211

H302, H315, H319, H335

Isotope-Labeled Compounds

Others

Neurological Disease

99.1

10 mM in DMSO

[2H]OC(C([2H])([2H])N(C([2H])([2H])C(O[2H])=O)C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C(O[2H])=O)C([2H])([2H])C(O[2H])=O)=O

C10D16N2O8

308.34

H302, H315, H319, H335

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011 May 1;412 (1) :34-9. |[3]Banfi G, et al. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin Chem Lab Med. 200745 (5) :565-76. |[4]Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016 Jan-Feb10 (1) :58-62.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-Y0682S1/

Isotope-Labeled Compounds

No Development Reported