FBXO5 Antilichaam - C-terminaal gebied: Biotine (ARP43125_P050-Biotine)

F-box protein 5

EMI1, FBX5, Fbxo31

26271

Q9UKT4

NP_036309

Human, Dog, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the C terminal region of human FBXO5

FBXO5 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein belongs to the Fbxs class and is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

FBXW11; UBE2S; SKP1; UBC; TPM3; NEDD8; BRCA1; BARD1; ANAPC1; ANAPC11; ANAPC7; ANAPC5; FZR1; ANAPC4; ANAPC2; CDC16; CDC23; CDC27; CDC20; CDK1; MYC; Gm9174; BTRC; PLK1; EVI5

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Dog: 85%; Human: 100%; Pig: 79%; Rabbit: 92%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

50kDa

Estrabaud, E., PLoS Pathog. 3 (7), E104 (2007)

Wet Ice

447

FBXO5

FBXO5

Rabbit

F-box only protein 5

NM_012177

ASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHNEFSEVAKTLKKNESL