Fosfo-14-3-3 beta + zeta (Ser186 / Ser184) Polyklonale Antilichaam, AbBy FluorTM 488 Vervoeging

Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axonally transported to the nerve terminals. They are also present, at lower levels, in various other eukaryotic tissues. 14-3-3 proteins appear to play important roles in a variety of signal transduction pathways, including those involved in cell cycle regulation and cell survival. Because 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. Evidence indicates 14-3-3 is required for Raf 1 kinase activity and phosphorylation amoung many other functions.

14-3-3 beta + zeta (phospho S184 + S186) ; 14-3-3 beta + zeta (phospho S186) ; 14-3-3 beta + zeta (phospho Ser186) ; p-14-3-3 beta + zeta (Ser186) 14 3 3 protein beta; 14 3 3 protein beta/alpha; 14 3 3 protein zeta/delta; 14 3 3 zeta; HS1; KCIP1; YWHAB; YWHAZ.

7529

P31946

Ser186 / Ser184

Cytoplasm, Cell membrane

Human, Mouse, Rat

Phospho-14-3-3 beta + zeta (Ser186 / Ser184)

AbBy Fluor™ 488

KLH conjugated synthesised phosphopeptide derived from human 14-3-3 beta + zeta around the phosphorylation site of Ser186 / Ser184

WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

499nm/519nm

1µg/µl

WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Phosphorylation

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

7529

Dog, Cow, Pig, Horse, Chicken