Galectine-3/galectine-8-IN-1

Galectin-3/galectin-8-IN-1 (Compound 53) is a dual Galectin-3 and galectin-8 C-terminal domain inhibitor, with Kd values of 4.12 μM and 6.04 μM respectively. Galectin-3/galectin-8-IN-1 inhibits the MRC-5 lung fibroblast cells migration. Galectin-3/galectin-8-IN-1 can be used for research of cancer and tissue fibrosis[1].

12352005

Galectin

Reference compound

Immunology/Inflammation

COVID-19-immunoregulation

Cancer; Inflammation/Immunology

https://www.medchemexpress.com/galectin-3-galectin-8-in-1.html

99.53

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

O=C(C(N1)=CC2=C1C=CC(OC3=CC=C(Cl)C(Cl)=C3)=C2)NS(=O)(C4=CC=C5N=CSC5=C4)=O

C22H13Cl2N3O4S2

518.39

[1]Haoming Zhang, et al. Discovery of N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Galectin-3 and Galectin-8 C-Terminal Domain Inhibitors. ACS Med. Chem. Lett. 2023, 14, 9, 1257-1265.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-155191/Galectin-3-galectin-8-IN-1-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported

Galectin-3; Galectin-8