GALR2 Antilichaam - C-terminalgebied: HRP (ARP61395 P050-HRP)

Galanin receptor 2

GAL2-R, GALNR2, GALR-2

8811

O43603

NP_003848

Human, Horse

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.

GNAQ; GAL

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

GALR2 is supported by BioGPS gene expression data to be expressed in A549

0.5 mg/ml

Horse: 93%; Human: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

43kDa

Wet Ice

387

GALR2

GALR2

Rabbit

Galanin receptor type 2

NM_003857

RGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPK