GCF2/LRRFIP1 Polyklonale Antilichaam, PE Vervoeging

LRRFIP1 is an 738 amino acid human protein whose rodent counterpart is known as Lrrfip1 (also designated FLAP in mouse) . LRRFIP1 is also believed to control smooth muscle cell proliferation following arterial injury through PDGF-A repression. The N-terminus of LRRFIP1 shows high homology to the coiled-coil domain of FLAP, a protein which binds the leucine-rich repeat (LRR) of Flightless I, and the interaction of LRRFIP1 with the LRR of Flightless I has been confirmed. LRRFIP1 does not bind single-stranded DNA or RNA significantly and binds double-stranded DNA weakly. In contrast, LRRFIP1 binds double-stranded RNA with high affinity, and two molecules of LRRFIP1 bind the TaR stem. The RNA binding domain has been identified and encompasses a lysine-rich motif. Flightless I has a C-terminal TaR-like domain which binds Actin and therefore the association of LRRFIP1 with the LRR of Flightless I may provide a link between the Actin cytoskeleton and RNA in mammalian cells.

FLAP 1; FLAP1; FLIIAP 1; FLIIAP1; GC binding factor 2; GC-binding factor 2; GCF 2; GCF2; HUFI 1; HUFI1; Leucine rich repeat in FLII interacting protein 1; Leucine rich repeat flightless interacting protein 1; Leucine-rich repeat flightless-interacting protein 1; LRR FLII interacting protein 1; LRR FLII-interacting protein 1; LRRF1_HUMAN; LRRFIP 1; Lrrfip1; MGC10947; MGC119738; MGC119739; NEDD8 conjugating enzyme; TAR RNA interacting protein; TAR RNA-interacting protein; Transcription factor 9 like; TRIP.

9208

Cytoplasm, Nucleus

121-220/808

GCF2/LRRFIP1

PE

KLH conjugated synthetic peptide derived from human LRRFIP1

IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

496,564nm/578nm

1µg/µl

IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

9208

Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse