GUTTIFERON G

Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively) . Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL) . Guttiferone G can be isolated from Garcinia macrophylla[1][2].

666174-75-0

12352005

Sirtuin

Natural Products

Cell Cycle/DNA Damage; Epigenetics

Cancer-programmed cell death

Others

https://www.medchemexpress.com/guttiferone-g.html

10 mM in DMSO

C/C(C)=C/C[C@](C([C@]12C/C=C(C)/C)=O)(C(C(C(C(C=C3)=CC(O)=C3O)=O)=C1O)=O)[C@](C)([C@@H](C2)C/C=C(C)/CC/C=C(C)/C)CC/C=C(C)/C

C43H58O6

670.92

[1]Williams RB, et al. A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest. Planta Med. 2003 Sep;69 (9) :864-6.|[2]Gey C, et al. Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2. Angew Chem Int Ed Engl. 2007;46 (27) :5219-22.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N9892/

Natural Products

No Development Reported