HDAC4 (Ab 632) Antilichaam

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

9759

P56524

NP_006028.2

Human, Mouse, Rat

HDAC4 (Ab-632) antibody was raised against a peptide sequence around aa. 630~634 (A-Q-S-S-P) derived from Human HDAC4.

Unconjugated

Primary Antibodies

Cell Cycle

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

140 kDa

This antibody detects endogenous level of total HDAC4 protein.

Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

HDAC4

Histone deacetylase 4

Homo sapiens

Wang AH, et al. (2000) Mol Cell Biol. 20 (18) : 6904-6912. Grozinger CM, et al. (2000) Proc Natl Acad Sci U S A. 97 (14) : 7835-7840.

HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A, HD4, Histone deacetylase 4

WB, IF

153085395

Liquid