HERV-FRD Antilichaam - N-terminalgebied: FITC (ARP56008 P050-FITC)

Endogenous retrovirus group FRD, member 1

EnvFRD, UNQ6191, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD

405754

P60508

NP_997465

Human

The immunogen is a synthetic peptide directed towards the N terminal region of human HERV-FRD

Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. HERV-FRD can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.Human endogenous retroviruses (HERVs) make up approximately 8% of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]) .[supplied by OMIM].

APP

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Human: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

60kDa

Malassine, A., (er) Retrovirology 5, 6 (2008)

Wet Ice

538

ERVFRD-1

ERVFRD-1

Rabbit

HERV-FRD_6p24.1 provirus ancestral Env polyprotein

NM_207582

TGSPYSTNCWLCTSSSTETPGTAYPASPREWTSIEAELHISYRWDPNLKG