HLA-DMA Antilichaam - N-terminaal gebied : HRP (ARP61256 P050-HRP)

Major histocompatibility complex, class II, DM alpha

DMA, HLADM, RING6, D6S222E

3108

Q31604

NP_006111

Human, Rat, Dog, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human HLA-DMA

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.

B3GAT1; U2AF2; RUNX1; UBC; CD82; HLA-DRB1; HLA-DOA; HLA-DRA; HLA-DMB; CD74

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Dog: 77%; Human: 100%; Rabbit: 82%; Rat: 86%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

29kDa

Wet Ice

261

HLA-DMA

HLA-DMA

Rabbit

DMA protein EMBL CAA60781.1

NM_006120

GLSEAYDEDQLFFFDFSQNTRVPRLPEFADWAQEQGDAPAILFDKEFCEW