HLA-F Antilichaam - N-terminalgebied: HRP (ARP49411_P050-HRP)

Major histocompatibility complex, class I, F

HLAF, CDA12, HLA-5.4, HLA-CDA12

3134

P30511

NP_001091949

Human, Cow, Pig

The immunogen is a synthetic peptide directed towards the N terminal region of human HLA-F

HLA-F belongs to the HLA class I heavy chain paralogues. It is a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.

UBC; LILRB2; LILRB1; TAP1; HLA-F; B2M

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

Affinity Purified

HLA-F is strongly supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Cow: 93%; Human: 100%; Pig: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

48kDa

Burfoot, R.K., (2008) Tissue Antigens 71 (1), 42-50

Wet Ice

442

HLA-F

HLA-F

Rabbit

HLA class I histocompatibility antigen, alpha chain F

NM_001098479

EAGSHTLQGMNGCDMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTAADT