IKZF3 Antilichaam - N-terminalgebied: HRP (ARP39004 P050-HRP)

IKAROS family zinc finger 3 (Aiolos)

AIO, AIOLOS, ZNFN1A3

22806

Q9UKT9-2

NP_899051

Human, Mouse, Rat, Cow, Dog, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human IKZF3

IKZF3 is a member of the Ikaros family of zinc-finger proteins. It is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers.This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoetic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.

STAMBPL1; EXOSC5; LGALS14; CABP5; PCID2; RCOR3; TBC1D22B; FANCL; MAGOHB; C1orf109; OAZ3; SPG21; CHCHD2; OSGIN1; POLM; PPP1R16B; ABLIM3; IKZF3; NEK6; FARS2; MRPL28; KAT5; BCAS2; AKAP9; FAM115A; EMC2; POLR1C; STX11; STK16; RAD51D; PSMA1; PRKAB2; PRKAA1; PIN

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

Affinity Purified

0.5 mg/ml

Cow: 86%; Dog: 86%; Human: 100%; Mouse: 86%; Pig: 86%; Rabbit: 86%; Rat: 86%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

52kDa

Koipally, J. (2002) J. Biol. Chem. 277 (31), 27697-27705

Wet Ice

453

IKZF3

IKZF3

Rabbit

Zinc finger protein Aiolos

NM_183228

KSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDDSMKV